VARIABLES PREDICTING ORAL MUCOSAL LESIONS IN ALLOGENIC BONE-MARROW RECIPIENTS

被引：20

作者：

MATTSSON, T

HEIMDAHL, A

DAHLLOF, G

NILSSON, B

LONNQVIST, B

RINGDEN, O

机构：

[1] KAROLINSKA INST, DEPT PEDODONT, S-14104 HUDDINGE, SWEDEN

[2] KAROLINSKA INST, MED DIV CLIN HEMATOL & ONCOL, S-14104 HUDDINGE, SWEDEN

[3] KAROLINSKA INST, DEPT CANC EPIDEMIOL, S-14104 HUDDINGE, SWEDEN

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 1991年 / 13卷 / 03期

关键词：

D O I：

10.1002/hed.2880130311

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

One hundred and forty-eight (72%) of 205 allogenic bone marrow transplant recipients developed mucosal lesions in the oral cavity during the aplastic period after transplantation. Lesions were most frequent 8 to 9 days after transplantation. Factors that correlated with the development of mucosal lesions after univariate and multivariate analysis were a marrow cell dose of < 3 x 10(8) cells/kg body weight, (p < 0.0001), prolonged aplastic period (white blood cell count < 0.2 x 10(9) cell/l during more than 14 days (p < 0.005), herpes simplex virus-1 seropositivity of the recipient (p < 0.01), and conditioning with total body irradiation (p < 0.02).

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页码：224 / 229

页数：6

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