INDUCTION OF 7-ETHOXYRESORUFIN-O-DEETHYLASE (EROD) ACTIVITY IN MICE FETUSES BY THE PCB-CONGENER 3,3',4,4'-TETRACHLOROBIPHENYL

被引:23
作者
SINJARI, T
TORNWALL, U
DARNERUD, PO
机构
[1] Department of Toxicology, BMC, Uppsala, S-751 24
关键词
D O I
10.3109/00498259309059366
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. 3,3',4,4'-Tetrachlorobiphenyl (TCB) induces liver microsomal 7-ethoxyresorufin-O-deethylase (EROD) activity, and this P450 isoform, i.e. CYP 1, is involved in the metabolism of TCB. 2. TCB administered i.p. to pregnant mice (5-25 mg/kg) induced foetal as well as maternal hepatic EROD activity; in all cases the maternal induced activity was higher than the foetal activity. EROD activity of TCB-induced foetuses increased with developmental age, but decreased with the length of time after treatment. 3. Strain differences were seen; in control mice and TCB-treated dams NMRI > C57BL in EROD activity, but in transplacentally TCB-treated foetuses, C57BL > NMRI. EROD activity in non-pregnant control C57BL mice was higher than in pregnant ones, whereas no activity was seen in control foetuses. 4. Results indicate that TCB at a certain dose can induce foetal metabolism, but that earlier observed foetal accumulation at lower TCB doses is probably a consequence of transplacental transport of maternally-produced metabolites.
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页码:107 / 114
页数:8
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