EXPRESSION OF NEUROFIBROMIN, THE NEUROFIBROMATOSIS-1 GENE-PRODUCT - STUDIES IN HUMAN NEUROBLASTOMA-CELLS AND RAT-BRAIN

被引：15

作者：

HUYNH, DP ^{[1
]}

LIN, CT ^{[1
]}

PULST, SM ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,DIV NEUROL,8700 BEVERLY BLVD,LOS ANGELES,CA 90048

来源：

NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期

关键词：

NEUROFIBROMATOSIS-1; VONRECKLINGHAUSEN DISEASE; NEUROFIBROMIN; ANTIBODY; RAT SPINAL CORD; GTPASE-ACTIVATING PROTEIN; WESTERN BLOT;

D O I：

10.1016/0304-3940(92)90272-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurofibromatosis type 1 (NF1) is one of the most frequent Mendelian disorders in man and one of the most common autosomal dominant disorders affecting the nervous system. The NF1 gene has recently been cloned, and shows homology to the GTPase activating protein. In order to characterize the NF1 gene product, now called neurofibromin, we raised polyclonal antibodies against C- and N-terminal regions of neurofibromin and analyzed the protein by Western blot analysis and immunohistochemical studies of rat brain.

引用

页码：233 / 236

页数：4

共 15 条

[1] SEQUENCE HOMOLOGY SHARED BY NEUROFIBROMATOSIS TYPE-1 GENE AND IRA-1 AND IRA-2 NEGATIVE REGULATORS OF THE RAS CYCLIC-AMP PATHWAY [J].

BUCHBERG, AM ;

CLEVELAND, LS ;

JENKINS, NA ;

COPELAND, NG .

NATURE, 1990, 347 (6290) :291-294

[2] A MAJOR SEGMENT OF THE NEUROFIBROMATOSIS TYPE-1 GENE - CDNA SEQUENCE, GENOMIC STRUCTURE, AND POINT MUTATIONS [J].

CAWTHON, RM ;

WEISS, R ;

XU, GF ;

VISKOCHIL, D ;

CULVER, M ;

STEVENS, J ;

ROBERTSON, M ;

DUNN, D ;

GESTELAND, R ;

OCONNELL, P ;

WHITE, R .

CELL, 1990, 62 (01) :193-201

[3]

DECLUE JE, 1991, P NATL ACAD SCI USA, V88, P9614

[4] THE GTPASE STIMULATORY ACTIVITIES OF THE NEUROFIBROMATOSIS TYPE-1 AND THE YEAST IRA2 PROTEINS ARE INHIBITED BY ARACHIDONIC-ACID [J].

GOLUBIC, M ;

TANAKA, K ;

DOBROWOLSKI, S ;

WOOD, D ;

TSAI, MH ;

MARSHALL, M ;

TAMANOI, F ;

STACEY, DW .

EMBO JOURNAL, 1991, 10 (10) :2897-2903

[5] IDENTIFICATION OF THE NEUROFIBROMATOSIS TYPE-1 GENE-PRODUCT [J].

GUTMANN, DH ;

WOOD, DL ;

COLLINS, FS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) :9658-9662

[6] REGULATION OF RAS-GAP AND THE NEUROFIBROMATOSIS-1 GENE-PRODUCT BY EICOSANOIDS [J].

HAN, JW ;

MCCORMICK, F ;

MACARA, IG .

SCIENCE, 1991, 252 (5005) :576-579

[7] THE GAP-RELATED DOMAIN OF THE NEUROFIBROMATOSIS TYPE-1 GENE-PRODUCT INTERACTS WITH RAS P21 [J].

MARTIN, GA ;

VISKOCHIL, D ;

BOLLAG, G ;

MCCABE, PC ;

CROSIER, WJ ;

HAUBRUCK, H ;

CONROY, L ;

CLARK, R ;

OCONNELL, P ;

CAWTHON, RM ;

INNIS, MA ;

MCCORMICK, F .

CELL, 1990, 63 (04) :843-849

[8] COEXISTENCE OF EGG-LAYING HORMONE AND A-BAG CELL PEPTIDE IN BAG CELL NEURONS OF APLYSIA INDICATES THAT THEY ARE A PEPTIDERGIC MULTITRANSMITTER SYSTEM [J].

PULST, SM ;

GUSMAN, D ;

ROTHMAN, BS ;

MAYERI, E .

NEUROSCIENCE LETTERS, 1986, 70 (01) :40-45

[9]

PULST SM, 1991, PRENATAL DIAGNOSIS N

[10] BRAIN-TUMORS PREDOMINANTLY EXPRESS THE NEUROFIBROMATOSIS TYPE-1 GENE TRANSCRIPTS CONTAINING THE 63 BASE INSERT IN THE REGION CODING FOR GTPASE ACTIVATING PROTEIN-RELATED DOMAIN [J].

SUZUKI, Y ;

SUZUKI, H ;

KAYAMA, T ;

YOSHIMOTO, T ;

SHIBAHARA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (03) :955-961

← 1 2 →