SIMULTANEOUS OCCURRENCE OF T(14-1) AND T(8-22) COMMON ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：15

作者：

MAROSI, C

BETTELHEIM, P

CHOTT, A

KOLLER, U

KREINER, G

STEGER, G

JAGER, U

PIRCDANOEWINATA, H

LECHNER, K

机构：

[1] UNIV VIENNA, DEPT MED 1, A-1010 VIENNA, AUSTRIA

[2] UNIV VIENNA, DEPT SMALL ANIM MED & SURG, A-1010 VIENNA, AUSTRIA

[3] UNIV VIENNA, INST IMMUNOL, A-1010 VIENNA, AUSTRIA

来源：

ANNALS OF HEMATOLOGY | 1992年 / 64卷 / 02期

关键词：

LYMPHOID NEOPLASIA; SPECIFIC CHROMOSOMAL ABERRATION; TUMOR PROGRESSION;

D O I：

10.1007/BF01715354

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A young male patient progressed rapidly from localized abdominal lymph node enlargement to overt acute lymphoblastic leukemia. Despite aggressive treatment, he died of progressive CNS leukemia 5 months after initial presentation. At diagnosis, karyotypic analysis of an abdominal lymph node revealed the coexistence of t (14; 18) (q32; q21), specific for follicular lymphoma, and t (8; 22) (q24; q11), a variant Burkitt translocation. Such cases might be considered as a model for a general mechanism of tumor progression with cascade-like involvement of oncogenes.

引用

收藏

页码：101 / 104

页数：4

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