THE PROTOONCOGENE BCL-2 INHIBITS APOPTOSIS IN PC12 CELLS

被引：236

作者：

MAH, SP ^{[1
]}

ZHONG, LT ^{[1
]}

LIU, Y ^{[1
]}

ROGHANI, A ^{[1
]}

EDWARDS, RH ^{[1
]}

BREDESEN, DE ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED,DEPT NEUROL,REED NEUROL RES CTR, 710 WESTWOOD PLAZA, LOS ANGELES, CA 90024 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 1993年 / 60卷 / 03期

关键词：

APOPTOSIS; BCL-2; NEUROTROPHIC FACTORS; PC12-CELLS;

D O I：

10.1111/j.1471-4159.1993.tb03275.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During development, many neuronal populations undergo a process of normal, programmed cell death, or apoptosis. Trophic factors regulate this process, but the mechanism by which they suppress apoptosis remains unclear. In the immune system, recent studies have implicated the protooncogene bcl-2 in the lymphocyte survival response to growth factors. To determine whether a similar survival pathway exists in a neuroendocrine cell type, we have expressed bcl-2 in the rat pheochromocytoma PC12 cell line and found that it abrogates the requirement for stimulation by growth factors to survive. bcl-2 expression also substantially delays the onset of injury by the calcium ionophore A23187.

引用

页码：1183 / 1186

页数：4

共 18 条

[1] AURINTRICARBOXYLIC ACID RESCUES PC12 CELLS AND SYMPATHETIC NEURONS FROM CELL-DEATH CAUSED BY NERVE GROWTH-FACTOR DEPRIVATION - CORRELATION WITH SUPPRESSION OF ENDONUCLEASE ACTIVITY
BATISTATOU, A
GREENE, LA
[J]. JOURNAL OF CELL BIOLOGY, 1991, 115 (02) : 461 - 471
[2] APOPTOTIC CELL-DEATH INDUCED BY C-MYC IS INHIBITED BY BCL-2
BISSONNETTE, RP
ECHEVERRI, F
MAHBOUBI, A
GREEN, DR
[J]. NATURE, 1992, 359 (6395) : 552 - 554
[3] PREVENTION OF PROGRAMMED CELL-DEATH OF SYMPATHETIC NEURONS BY THE BCL-2 PROTOONCOGENE
GARCIA, I
MARTINOU, I
TSUJIMOTO, Y
MARTINOU, JC
[J]. SCIENCE, 1992, 258 (5080) : 302 - 304
[4] ACTIVATED N-RAS GENE INDUCES NEURONAL DIFFERENTIATION OF PC12 RAT PHEOCHROMOCYTOMA CELLS
GUERRERO, I
WONG, H
PELLICER, A
BURSTEIN, DE
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1986, 129 (01) : 71 - 76
[5] BCL-2 IS AN INNER MITOCHONDRIAL-MEMBRANE PROTEIN THAT BLOCKS PROGRAMMED CELL-DEATH
HOCKENBERY, D
NUNEZ, G
MILLIMAN, C
SCHREIBER, RD
KORSMEYER, SJ
[J]. NATURE, 1990, 348 (6299) : 334 - 336
[6] BCL2 PROTEIN IS TOPOGRAPHICALLY RESTRICTED IN TISSUES CHARACTERIZED BY APOPTOTIC CELL-DEATH
HOCKENBERY, DM
ZUTTER, M
HICKEY, W
NAHM, M
KORSMEYER, SJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) : 6961 - 6965
[7] ROLE OF CA-2+ CHANNELS IN THE ABILITY OF MEMBRANE DEPOLARIZATION TO PREVENT NEURONAL DEATH INDUCED BY TROPHIC-FACTOR DEPRIVATION - EVIDENCE THAT LEVELS OF INTERNAL CA-2+ DETERMINE NERVE GROWTH-FACTOR DEPENDENCE OF SYMPATHETIC-GANGLION CELLS
KOIKE, T
MARTIN, DP
JOHNSON, EM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) : 6421 - 6425
[8] KORSMEYER SJ, 1990, CURR TOP MICROBIOL, V166, P203
[9] A SAFE PACKAGING LINE FOR GENE-TRANSFER - SEPARATING VIRAL GENES ON 2 DIFFERENT PLASMIDS
MARKOWITZ, D
GOFF, S
BANK, A
[J]. JOURNAL OF VIROLOGY, 1988, 62 (04) : 1120 - 1124
[10] ADVANCED MAMMALIAN GENE-TRANSFER - HIGH TITER RETROVIRAL VECTORS WITH MULTIPLE-DRUG SELECTION MARKERS AND A COMPLEMENTARY HELPER-FREE PACKAGING CELL-LINE
MORGENSTERN, JP
LAND, H
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (12) : 3587 - 3596

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