SKIN VASCULAR REACTIVITY TO THE NEUROPEPTIDE SUBSTANCE-P IN RATS WITH PERIPHERAL MONONEUROPATHY

被引:23
作者
BASILE, S
KHALIL, Z
HELME, RD
机构
[1] National Research Institute of Gerontology and Geriatric Medicine, North West Hospital, Parkville
关键词
NEUROPATHY; INFLAMMATION; BLISTER MODEL; SUBSTANCE-P; (RAT);
D O I
10.1016/0304-3959(93)90134-B
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
A compression neuropathy model that produces pain-related behaviour in rats was used to investigate changes in skin vascular reactivity in the innervated area. Neuropathy was produced by 4 ligatures tied loosely around the common sciatic nerve. Vascular reactivity was assessed via perfusion of the neuropeptide substance P (SP) over the base of a blister raised on the rat foot pad. Compared to sham-operated rats, experimental rats exhibited a decrease in their vasodilatation response to SP 2-5 weeks after ligatures were tied. A bilateral decrease in vasodilatation to sodium nitroprusside perfusion in treated rats suggested part of the altered SP response was due to diminished vascular reactivity. Plasma extravasation in response to SP was also decreased on the operated side of ligatured rats, significant 4 and 6 weeks after the operation. The results support studies that suggest neurogenic inflammation is altered in chronic neuropathic pain states.
引用
收藏
页码:217 / 222
页数:6
相关论文
共 23 条
  • [1] TACHYKININ-INDUCED VASODILATATION IN RAT SKIN MEASURED WITH A LASER-DOPPLER FLOWMETER - EVIDENCE FOR RECEPTOR-MEDIATED EFFECTS
    ANDREWS, PV
    HELME, RD
    [J]. REGULATORY PEPTIDES, 1989, 25 (03) : 267 - 275
  • [2] NK-1 RECEPTOR MEDIATION OF NEUROGENIC PLASMA EXTRAVASATION IN RAT SKIN
    ANDREWS, PV
    HELME, RD
    THOMAS, KL
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (04) : 1232 - 1238
  • [3] FURTHER EVIDENCE FOR PAIN-RELATED BEHAVIORS IN A MODEL OF UNILATERAL PERIPHERAL MONONEUROPATHY
    ATTAL, N
    JAZAT, F
    KAYSER, V
    GUILBAUD, G
    [J]. PAIN, 1990, 41 (02) : 235 - 251
  • [4] A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN
    BENNETT, GJ
    XIE, YK
    [J]. PAIN, 1988, 33 (01) : 87 - 107
  • [5] BENNETT GJ, 1989, PROCESSING SENSORY I, P463
  • [6] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
  • [7] RSI REVISITED - EVIDENCE FOR PSYCHOLOGICAL AND PHYSIOLOGICAL DIFFERENCES FROM AN AGE, SEX AND OCCUPATION MATCHED CONTROL-GROUP
    HELME, RD
    LEVASSEUR, SA
    GIBSON, SJ
    [J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1992, 22 (01): : 23 - 29
  • [8] KAJANDER K C, 1989, Society for Neuroscience Abstracts, V15, P816
  • [9] KAJANDER K C, 1988, Society for Neuroscience Abstracts, V14, P912
  • [10] SEQUENCE OF EVENTS IN SUBSTANCE-P-MEDIATED PLASMA EXTRAVASATION IN RAT SKIN
    KHALIL, Z
    HELME, RD
    [J]. BRAIN RESEARCH, 1989, 500 (1-2) : 256 - 262