SYNTHETIC STUDIES ON POLYPROPIONATE ANTIBIOTICS BASED ON THE STEREOSPECIFIC METHYLATION OF GAMMA,DELTA-EPOXY ACRYLATES BY TRIMETHYLALUMINUM - A HIGHLY STEREOSELECTIVE CONSTRUCTION OF THE 8 CONTIGUOUS CHIRAL CENTERS OF ANSA-CHAINS OF RIFAMYCINS

被引：31

作者：

MIYASHITA, M ^{[1
]}

YOSHIHARA, K ^{[1
]}

KAWAMINE, K ^{[1
]}

HOSHINO, M ^{[1
]}

IRIE, H ^{[1
]}

机构：

[1] KAO CORP,BIOL SCI LABS,TOCHIGI 32134,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)73733-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly stereoselective construction of the eight contiguous chiral centers of ansa-chains of rifamycins has been accomplished by the iterative use of the stereospecific methylation of gamma,delta-epoxy acrylates by trimethylaluminum which was recently developed by us. The present work demonstrates the synthetic potential of the method for the synthesis of polypropionate antibiotics including ansamycins and macrolides.

引用

页码：6285 / 6288

页数：4

共 22 条

[1] STEREOSELECTIVE SYNTHESIS OF THE C(19)-TO-C(27) SEGMENT OF RIFAMYCIN-S [J].