NE-100, A NOVEL SIGMA-RECEPTOR LIGAND - EFFECT ON PHENCYCLIDINE-INDUCED BEHAVIORS IN RATS, DOGS AND MONKEYS

被引：24

作者：

OKUYAMA, S ^{[1
]}

IMAGAWA, Y ^{[1
]}

SAKAGAWA, T ^{[1
]}

NAKAZATO, A ^{[1
]}

YAMAGUCHI, K ^{[1
]}

KATOH, M ^{[1
]}

YAMADA, S ^{[1
]}

ARAKI, H ^{[1
]}

OTOMO, S ^{[1
]}

机构：

[1] NIHON BIORES CTR INC,GIFU 50162,JAPAN

来源：

LIFE SCIENCES | 1994年 / 55卷 / 07期

关键词：

PHENCYCLIDINE; SIGMA LIGAND; SCHIZOPHRENIA;

D O I：

10.1016/0024-3205(94)00749-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Phencyclidine (PCP)-induced psychosis is a useful animal model for studies on schizophrenia. N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]-ethylamine monohydrochloride (NE-100) had no effect on conditioned avoidance responses (CAR) in rats, whereas, the PCP-induced impairment of avoidance inhibition was attenuated by NE-100. The PCP-induced ataxia or decreased attention in rhesus monkeys was to some extent overcome by NE100. In dogs, PCP-induced either head-weaving behavior or ataxia, effects which were blocked by NE-100. Administration of PCP led to an increase in beta-2 and a decrease in delta relative power (RP) activity in cortical background spectral electroencephalographics (ECoG) in dogs. While NE-100 in itself showed no significant change in beta-2 and delta RP, NE-100 did block the PCP-induced beta-2 increase and delta decrease. These findings indicate that NE-100 attenuates the effect of PCP in experimental animals. This drug is being considered as a therapeutic for the treatment of paients in the schizophrenia.

引用

页码：PL133 / PL138

页数：6

共 23 条

[1] PSYCHOMOTOR ACTIVITY AND COGNITIVE DISRUPTION ATTRIBUTABLE TO NMDA, BUT NOT SIGMA, INTERACTIONS IN PRIMATES [J].