IRRITABLE-BOWEL-SYNDROME COULD BE AN INFLAMMATORY DISORDER

被引：18

作者：

COLLINS, SM

机构：

[1] Division of Gastroenterology, McMaster University, Hamilton, ON

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1994年 / 6卷 / 06期

关键词：

INFLAMMATION; CYTOKINES; SUBSTANCE-P; INTERLEUKINS; MAST CELLS; FUNCTIONAL BOWEL DISORDERS;

D O I：

10.1097/00042737-199406000-00005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recent research has demonstrated that enteric neural and smooth muscle function is modulated by the immune system and influenced by mucosal inflammation. In addition, there is increasing awareness of the ability of the brain to modulate immune function and inflammatory processes in the periphery. These developments, taken in conjunction with observations of increased inflammatory cell levels in the gut of some patients with irritable bowel syndrome, provide the basis for considering inflammation as a putative pathophysiological process underlying gastrointestinal dysfunction in at least a subset of patients with this syndrome.

引用

页码：478 / 482

页数：5

共 30 条

[1]

Mayer E.A., Raybould H.E., Role of visceral afferent mechanisms in functional bowel disorders, Gastroenterology, 99, pp. 1688-1704, (1990)

[2]

Bergin A.J., Donnelly T.C., McKendrick M.W., Read N.W., Changes in anorectal function in persistent bowel disturbance following salmonella gastroenteritis, Eur J Gastroenterol Hepatol, 5, pp. 617-620, (1993)

[3]

Snape W.J., Williams R., Hyman P.E., Defect in colonic muscle contraction in patients with ulcerative colitis, Am J Physiol, 261, pp. G987-G991, (1991)

[4]

Vermillion D.L., Huizinga J.D., Riddell R.H., Collins S.M., Altered small intestinal smooth muscle function in Crohn's disease, Gastroenterology, 104, pp. 1692-1699, (1993)

[5]

Marzio L., Blennerhassett P., Chiverton S., Vermillion D.L., Langer J., Collins S.M., Altered smooth muscle function in worm-free gut regions of Trichinella-infected rats, Am J Physiol, 259, pp. G306-G313, (1990)

[6]

Scott R.B., Gall D.G., Marie M., Mediation of food protein-in-duced jejunal smooth muscle contraction in sensitized rats, Am J Physiol, 259, pp. G6-G14, (1990)

[7]

Vermillion D.L., Ernst P.B., Scicchitano R., Collins S.M., Antigen-induced contraction of jejunal smooth muscle in the sensitized rat, Am J Physiol, 255, pp. G701-G708, (1988)

[8]

Vermillion D.L., Ernst P.B., Collins S.M., T-lymphocyte modulation of intestinal muscle function in the Trichinella-infected rat, Gastroenterology, 101, pp. 31-38, (1991)

[9]

Collins S.M., Hurst S.M., Main C., Stanley E., Khan I., Blennerhassett P., Swain M., Effect of inflammation of enteric nerves. Cytokine-induced changes in neurotransmitter content and release, Ann NY Acad Sci, 644, pp. 415-424, (1992)

[10]

Grossi L., McHugh K., Collins S.M., On the specificity of altered muscle function in experimental colitis in rats, Gastroenterology, 104, pp. 1049-1056, (1993)

← 1 2 3 →