CLINICAL EVALUATION OF NETILMICIN THERAPY IN SERIOUS INFECTIONS

被引:21
作者
JAHRE, JA [1 ]
FU, KP [1 ]
NEU, HC [1 ]
机构
[1] COLUMBIA UNIV,COLL PHYS & SURG,DIV INFECT DIS,NEW YORK,NY 10032
关键词
D O I
10.1016/0002-9343(79)90484-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Netilmicin, a new semisynthetic aminoglycoside, was evaluated in the therapy of 33 episodes of infection in 30 patients. Eighteen patients had documented bacteremia. Infection sites included pulmonary, urinary tract and soft tissue areas. A complete bacteriologic and clinical cure rate of 85 per cent was achieved. No treatment failures occurred in the bacteremic group. Although netilmicin is less effective than gentamicin in vitro against Pseudomonas, it was clinically and bacteriologically effective. Netilmicin bacteriologic cures occurred in patients whose organisms were inhibited by 6.2 μg/ml or less of netilmicin. Despite a uniform dosing protocol, a wide range of netilmicin serum levels was obtained. Adverse effects were limited to one case of transient nephrotoxicity and one Candida urinary suprainfection. Netilmicin appears to be an effective, safe agent for the therapy of serious infections. © 1978.
引用
收藏
页码:67 / 73
页数:7
相关论文
共 9 条
[1]   RENAL PHARMACOLOGY OF NETILMICIN [J].
CHIU, PJS ;
MILLER, GH ;
BROWN, AD ;
LONG, JF ;
WAITZ, JA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (05) :821-825
[2]   INVITRO STUDY OF NETILMICIN COMPARED WITH OTHER AMINOGLYCOSIDES [J].
FU, KP ;
NEU, HC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (03) :526-534
[3]   COMPARATIVE TOXICITY OF NETILMICIN AND GENTAMICIN IN SQUIRREL-MONKEYS (SAIMIRI-SCIUREUS) [J].
IGARASHI, M ;
LEVY, JK ;
JERGER, J .
JOURNAL OF INFECTIOUS DISEASES, 1978, 137 (04) :476-480
[4]  
JAHRE JA, 1978, CLIN PHARMACOL THER, V23, P591
[5]   COMPARATIVE NEPHROTOXICITIES OF NETILMICIN AND GENTAMICIN IN RATS [J].
LUFT, FC ;
YUM, MN ;
KLEIT, SA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (05) :845-849
[6]   GRAM-NEGATIVE BACTEREMIA .1. ETIOLOGY AND ECOLOGY [J].
MCCABE, WR ;
JACKSON, GG .
ARCHIVES OF INTERNAL MEDICINE, 1962, 110 (06) :847-&
[7]   BIOLOGICAL-ACTIVITY OF NETILMICIN, A BROAD-SPECTRUM SEMISYNTHETIC AMINOGLYCOSIDE ANTIBIOTIC [J].
MILLER, GH ;
ARCIERI, G ;
WEINSTEIN, MJ ;
WAITZ, JA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (05) :827-836
[8]   NETILMICIN - CLINICAL EFFICACY, TOLERANCE, AND TOXICITY [J].
PANWALKER, AP ;
MALOW, JB ;
ZIMELIS, VM ;
JACKSON, GG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 13 (02) :170-176
[9]   ANTIBIOTIC-6640, A NEW MICROMONOSPORA-PRODUCED AMINOGLYCOSIDE ANTIBIOTIC [J].
WEINSTEIN, MJ ;
MARQUEZ, JA ;
TESTA, RT ;
WAGMAN, GH ;
ODEN, EM ;
WAITZ, JA .
JOURNAL OF ANTIBIOTICS, 1970, 23 (11) :551-+