SPONTANEOUS AND GRISEOFULVIN-INDUCED SEGREGATION FOR 8-AZAGUANINE RESISTANCE IN HYBRIDS FROM A HUMAN HETEROPLOID LINE

被引：9

作者：

LARIZZA, L ^{[1
]}

SIMONI, G ^{[1
]}

STEFANINI, M ^{[1
]}

CARLI, LD ^{[1
]}

机构：

[1] CNR,GENET BIOCHIM & EVOLUZIONISTICA LAB,I-27100 PAVIA,ITALY

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 120卷 / 02期

关键词：

D O I：

10.1016/0014-4827(79)90400-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Griseofulvin (GF) treatment was found to increase segregation of the 8AG-sensitive parental type in hybrids produced between HGPRT- and HGPRT+ clonal derivatives of the human heteroploid line EUE. Continued platings in 8AG medium after a period of growth in medium without 8AG revealed the same degree of stability of the character both in the spontaneous and the induced segregants. Induced segregation rate (ISR), i.e., the ratio between the frequency of 8AG-resistant colonies from treated and untreated cells, showed a marked variation among different hybrids. © 1979.

引用

页码：405 / 409

页数：5

共 9 条

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[J]. SCIENCE, 1964, 145 (363) : 709 - &
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[8] HETEROKARYON FORMATION BETWEEN ALKALINE PHOSPHATASE VARIANTS IN A HUMAN HETEROPLOID CELL LINE
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DECARLI, L
[J]. EUROPEAN JOURNAL OF CANCER, 1970, 6 (01) : 1 - &
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