SUPPRESSIVE EFFECTS OF INDOMETHACIN ON THERMALLY INDUCED NEOVASCULARIZATION OF RABBIT CORNEAS

被引:61
作者
DEUTSCH, TA
HUGHES, WF
机构
[1] RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT OPHTHALMOL,CHICAGO,IL 60612
[2] RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT ANAT,CHICAGO,IL 60612
关键词
D O I
10.1016/0002-9394(79)90245-9
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
In 16 rabbits with bilateral corneal burns, indomethacin was administered topically to one eye on each day after the lesion was made to determine the effect of a prostaglandin inhibitor on the corneal neovascular response to experimental thermal burns. Comparison of the two eyes showed a reduction of both hyperemia and neovascularization in indomethacin-treated eyes during the first five days after injury. Histologic observations during this period showed a reduction in polymorphonuclear cell infiltration in the treated corneas. Inhibition of prostaglandin synthesis by indomethacin apparently led to a reduction in the inflammatory response and the subsequent corneal neovascularization. © 1979.
引用
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页码:536 / 540
页数:5
相关论文
共 22 条
[1]  
BROWN SI, 1971, INVEST OPHTH VISUAL, V10, P203
[2]   INDOMETHACIN REDUCED RETINAL SENSITIVITY AND CORNEAL DEPOSITS [J].
BURNS, CA .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1968, 66 (05) :825-&
[3]  
CRABB CV, 1977, ARCH OPHTHALMOL-CHIC, V95, P1866
[4]  
FLOMAN N, 1977, INVEST OPHTH VIS SCI, V16, P69
[5]   TUMOR ANGIOGENESIS - POSSIBLE CONTROL POINT IN TUMOR-GROWTH [J].
FOLKMAN, J .
ANNALS OF INTERNAL MEDICINE, 1975, 82 (01) :96-100
[6]  
FRANCOIS J, 1973, EXP EYE RES, V15, P201
[7]  
FROMER CH, 1976, AM J PATHOL, V82, P157
[8]  
FROMER CH, 1975, AM J PATHOL, V81, P531
[9]  
FROMER CH, 1975, AM J PATHOL, V79, P537
[10]  
HANNA C, 1972, ARCH OPHTHALMOL-CHIC, V88, P196