PENTAMIDINE ACTIVATES T1 THE HEPATIC-MICROSOMAL GLUCOSE-6-PHOSPHATE TRANSPORT PROTEIN OF THE GLUCOSE-6-PHOSPHATASE SYSTEM

被引：8

作者：

SCOTT, HM ^{[1
]}

BURCHELL, A ^{[1
]}

机构：

[1] NINEWELLS HOSP & MED SCH,CTR RES HUMAN DEV,DEPT OBSTET & GYNAECOL,DUNDEE DD1 95Y,SCOTLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1097卷 / 01期

关键词：

GLUCOSE-6-PHOSPHATASE; GLUCOSE 6-PHOSPHATE TRANSPORT; MICROSOME; PENTAMIDINE;

D O I：

10.1016/0925-4439(91)90020-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of activation of hepatic microsomal glucose-6-phosphatase (EC 3.1.3.9) in vitro by pentamidine has been investigated in both intact and fully disrupted microsomes. The major effect of pentamidine is a 4.7-fold reduction in the K(m) of glucose-6-phosphatase activity in intact diabetic rat liver microsomes. The site of action of pentamidine is T1 the hepatic microsomal glucose 6-phosphate transport protein. The activation of T1 by pentamidine may contribute to the disturbed blood glucose homeostasis seen in many patients after the administration of the drug pentamidine.

引用

页码：31 / 36

页数：6

共 32 条

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