TRANSFERRIN RECEPTOR IN NORMAL AND NEOPLASTIC BRAIN-TISSUE - IMPLICATIONS FOR BRAIN-TUMOR IMMUNOTHERAPY

被引:163
作者
RECHT, L
TORRES, CO
SMITH, TW
RASO, V
GRIFFIN, TW
机构
[1] UNIV MASSACHUSETTS,MED CTR,DEPT PATHOL NEUROPATHOL,WORCESTER,MA 01605
[2] UNIV MASSACHUSETTS,MED CTR,DEPT MED ONCOL,WORCESTER,MA 01605
[3] BOSTON BIOL MED RES INST,BOSTON,MA
关键词
brain neoplasm; immunohistochemistry; Transferrin receptor; tumor cell proliferation;
D O I
10.3171/jns.1990.72.6.0941
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The distribution of transferrin receptor (TfR) in normal human brain-tissue obtained at autopsy and in brain-tumor biopsy specimens from 27 patients was determined by immunohistochemistry using two specific murine monoclonal antibodies against human TfR. The tumors studied included 10 glioblastomas multiforme (GBM's), nine other glial tumors, and eight meningiomas. In normal brain, TfR was detected primarily in endothelial cells; rare glial cells also contained immunoreactive product. All tumors contained TfR-positive cells, although the intensity (number of cells stained) and pattern (focal vs. diffuse) of staining varied with the histopathological type of the tumor. Among gliomas, the most intense staining was seen in GBM's, especially in areas of pseudopalisading where virtually all cells were stained. A rough correlation between tumor grade, number of positively stained cells, and staining pattern was seen in the other astrocytic tumors. By contrast, all meningiomas demonstrated an identical and characteristic focal staining pattern. Considering the differential immunostaining for TfR between normal and neoplastic tissue, the authors conclude that TfR may be an appropriate target for monoclonal antibody-directed brain-tumor immunotherapy, especially in more malignant tumors such as GBM's.
引用
收藏
页码:941 / 945
页数:5
相关论文
共 31 条
[1]  
BJORN MJ, 1987, CANCER RES, V47, P6639
[2]   THE USE OF THE MONOCLONAL-ANTIBODY KI-67 IN THE IDENTIFICATION OF PROLIFERATING CELLS - APPLICATION TO SURGICAL NEUROPATHOLOGY [J].
BURGER, PC ;
SHIBATA, T ;
KLEIHUES, P .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1986, 10 (09) :611-617
[3]   MORBIDITY, MORTALITY, AND QUALITY OF LIFE FOLLOWING SURGERY FOR INTRACRANIAL MENINGIOMAS - A RETROSPECTIVE STUDY IN 257 CASES [J].
CHAN, RC ;
THOMPSON, GB .
JOURNAL OF NEUROSURGERY, 1984, 60 (01) :52-60
[4]   SENSITIVITY OF HUMAN GLIOMA-CELLS TO CYTO-TOXIC HETEROCONJUGATES [J].
COLOMBATTI, M ;
BISCONTI, M ;
DELLARCIPRETE, L ;
GEROSA, MA ;
TRIDENTE, G .
INTERNATIONAL JOURNAL OF CANCER, 1988, 42 (03) :441-448
[5]  
Colombatti M, 1988, Acta Neurochir Suppl (Wien), V43, P121
[6]  
ENNS CA, 1981, J BIOL CHEM, V256, P9820
[7]  
FAULK WP, 1980, LANCET, V2, P390
[8]   TRANSFERRIN BINDING BY HUMAN-LYMPHOBLASTOID CELL-LINES AND OTHER TRANSFORMED-CELLS [J].
GALBRAITH, GMP ;
GALBRAITH, RM ;
FAULK, WP .
CELLULAR IMMUNOLOGY, 1980, 49 (01) :215-222
[9]   TRANSFERRIN RECEPTORS IN HUMAN-TISSUES - THEIR DISTRIBUTION AND POSSIBLE CLINICAL RELEVANCE [J].
GATTER, KC ;
BROWN, G ;
TROWBRIDGE, IS ;
WOOLSTON, RE ;
MASON, DY .
JOURNAL OF CLINICAL PATHOLOGY, 1983, 36 (05) :539-545
[10]  
GRIFFIN TW, 1987, CANCER RES, V47, P4266