INDUCTION OF CYSTATIN-S IN RAT SUBMANDIBULAR GLANDS BY PAPAIN

被引：15

作者：

NAITO, Y ^{[1
]}

SUZUKI, I ^{[1
]}

HASEGAWA, S ^{[1
]}

机构：

[1] SUZUKA COLL TECHNOL,SUZUKA 51002,JAPAN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1992年 / 102卷 / 04期

关键词：

D O I：

10.1016/0305-0491(92)90093-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Papain (a cysteine proteinase) were administered into the oral cavity of rats twice daily for 5 days. This treatment caused a dramatic increase in the level of cystatin S (a cysteine proteinase inhibitor belonging to family 2 of cystatin superfamily) in enlarged submandibular glands. 2. Immunochemical analysis using antibody against rat cystatin S and electrophoretic analysis confirmed that the protein induced by papain was identical to that induced by isoproterenol. 3. Induction of the cystatin S in the submandibular glands by oral administration of papain suggested a biological response which plays a role in preventing injury exogenous proteinase.

引用

页码：861 / 865

页数：5

共 28 条

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