MULTIPLE CONDUCTANCES OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS

被引：11

作者：

LEECH, CA

SATTELLE, DB

机构：

[1] AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, Downing Street

来源：

NEUROPHARMACOLOGY | 1992年 / 31卷 / 05期

关键词：

HOUSEFLY (MUSCA-DOMESTICA); NICOTINIC RECEPTOR; ACETYLCHOLINE; CONDUCTANCES;

D O I：

10.1016/0028-3908(92)90090-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the presence of acetylcholine, cationic channels with three different conductances were recorded from neurones of the dissociated housefly (Musca domestica). Large conductance (80 pS) channels, resembling those that are abundant in reconstitution studies with a 65 kDa alpha-bungarotoxin affinity purified polypeptide, were detected in situ. The two larger conductance channels (80 pS; 32 pS) exhibited open and closed times that were best fitted by multiple exponential functions, indicating the presence of at least two open states. A third conductance (20 pS) showed brief, sparse openings and was least frequently observed. The 32 pS channel was the most common.

引用

页码：501 / 507

页数：7

共 39 条

[1]

BEADLE CA, 1985, J PHYSIOL-LONDON, V371, pP145

[2]

BEADLE DJ, 1989, J EXP BIOL, V142, P337

[3] ACTIVATION AND BLOCKING OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR RECONSTITUTED IN XENOPUS OOCYTES [J].

BERTRAND, D ;

BALLIVET, M ;

RUNGGER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (05) :1993-1997

[4] FUNCTIONAL EXPRESSION OF 2 NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS FROM CDNA CLONES IDENTIFIES A GENE FAMILY [J].

BOULTER, J ;

CONNOLLY, J ;

DENERIS, E ;

GOLDMAN, D ;

HEINEMANN, S ;

PATRICK, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7763-7767

[5]

BREER H, 1985, J NEUROSCI, V5, P3386

[6] MOLECULAR-PROPERTIES AND FUNCTIONS OF INSECT ACETYLCHOLINE-RECEPTORS [J].

BREER, H ;

SATTELLE, DB .

JOURNAL OF INSECT PHYSIOLOGY, 1987, 33 (11) :771-790

[7] REGULATION OF ACETYLCHOLINE-RECEPTOR CHANNEL FUNCTION DURING DEVELOPMENT OF SKELETAL-MUSCLE [J].

BREHM, P ;

HENDERSON, L .

DEVELOPMENTAL BIOLOGY, 1988, 129 (01) :1-11

[8] ACETYLCHOLINE-RECEPTOR CHANNELS ON ADULT-MOUSE SKELETAL-MUSCLE ARE FUNCTIONALLY IDENTICAL IN SYNAPTIC AND NONSYNAPTIC MEMBRANE [J].

BREHM, P ;

KULLBERG, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2550-2554

[9]

BUCKINGHAM SD, 1989, J PHYSIOL-LONDON, V418, pP193

[10]

CHANGEUX JP, 1971, MOL PHARMACOL, V7, P538

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