ACQUIRED TAMOXIFEN RESISTANCE IN HUMAN BREAST-CANCER AND REDUCED INTRA-TUMORAL DRUG CONCENTRATION

被引:78
作者
JOHNSTON, SRD
HAYNES, BP
SMITH, IE
JARMAN, M
SACKS, NPM
EBBS, SR
DOWSETT, M
机构
[1] ROYAL MARSDEN HOSP,BREAST UNIT,LONDON SW3 6JJ,ENGLAND
[2] INST CANC RES,DRUG DEV SECT,SUTTON SM2 5PX,SURREY,ENGLAND
[3] MAYDAY UNIV HOSP,DEPT SURG,CROYDON,SURREY,ENGLAND
关键词
D O I
10.1016/S0140-6736(05)80088-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Reduced intra-tumoral drug concentrations have been investigated as a mechanism of tamoxifen resistance in 51 patients with locally recurrent breast cancer. Serum tamoxifen was similar in patients with acquired and de-novo resistance, but intra-tumoral concentrations were significantly lower in patients with acquired resistance. Tumour oestrogen-receptor concentrations at relapse did not support the hypothesis that selective outgrowth of oestrogen-receptor-negative cells is a major mechanism for acquired tamoxifen resistance. Reduced intra-tumoral tamoxifen levels during prolonged therapy may be an important mechanism for acquired resistance in breast cancer.
引用
收藏
页码:1521 / 1522
页数:2
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