THE INCIDENCE OF 2ND PRIMARY TUMORS IN LONG-TERM SURVIVORS OF SMALL-CELL LUNG-CANCER

被引:85
作者
HEYNE, KH [1 ]
LIPPMAN, SM [1 ]
LEE, JJ [1 ]
LEE, JS [1 ]
HONG, WK [1 ]
机构
[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT MED ONCOL,HEAD NECK & THORAC MED ONCOL SECT,BOX 80,HOUSTON,TX 77030
关键词
D O I
10.1200/JCO.1992.10.10.1519
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose and Methods: A review of 446 patients who were enrolled consecutively in small-cell lung cancer (SCLC) protocols was performed to identify in long-term survivors the frequency of new primary tumors and their clinical impact. Results: Forty-seven patients (10.5%) were identified to be free of disease at 2 years. Second primary tumors (SPTs) were diagnosed in 14 patients. The overall risk for developing an SPT was 10.3% per person-year. Actuarial risk at 8 years was 50.3% for an SPT. Conclusions: In this review, SCLC showed one of the highest incidences of SPTs reported in aerodigestive tract malignancies. A long-term survivor was more likely to have an SPT than a relapse of SCLC. Consequently, the odds of death from an SPT compared with that from a relapse increased sharply from 1:13 within 4 years from diagnosis to 8:1 afterwards. Long-term survivors of SCLC would be excellent candidates for chemoprevention trials.
引用
收藏
页码:1519 / 1524
页数:6
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