MEROPENEM VERSUS IMIPENEM-CILASTATIN IN THE TREATMENT OF INTRAABDOMINAL INFECTIONS REQUIRING SURGERY

被引:47
作者
KANELLAKOPOULOU, K [1 ]
GIAMARELLOU, H [1 ]
PAPADOTHOMAKOS, P [1 ]
TSIPRAS, H [1 ]
CHLOROYIANNIS, J [1 ]
THEAKOU, R [1 ]
SFIKAKIS, P [1 ]
机构
[1] UNIV ATHENS,LAIKO GEN HOSP,SCH MED,DEPT PROPEDEUT MED,GR-11527 ATHENS,GREECE
关键词
D O I
10.1007/BF01967440
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In a prospective randomized study meropenem was compared with imipenem/cilastatin in the treatment of 62 patients with intraabdominal infections requiring surgery. The patients were suffering from diffuse or local peritonitis of moderate severity complicating in most cases gangrenous appendicitis, stomach perforation or gallbladder disease. There were 30 patients in the meropenem group and 32 patients in the imipenem/cilastatin group. Both antibiotic regimens were given intravenously at a dosage of 1 g every 8 h for a mean duration of 7.7 days in the meropenem group versus 8.6 days in the imipenem/cilastatin group. Fifty-nine aerobic strains and 15 anaerobic strains were isolated from cultures of pus taken intraoperatively, the meropenem MICs ranging from less-than-or-equal-to 0.25 to 2 mug/ml. At follow-up at least one month after treatment the outcome was considered successful in all of 27 evaluable patients given meropenem and in all of 29 evaluable patients given imipenem/cilastatin. Both antibiotic regimens were well tolerated.
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页码:449 / 453
页数:5
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