SMALL, ACID-SOLUBLE PROTEINS BOUND TO DNA PROTECT BACILLUS-SUBTILIS SPARES FROM BEING KILLED BY FREEZE-DRYING

被引：34

作者：

FAIRHEAD, H

SETLOW, B

WAITES, WM

SETLOW, P

机构：

[1] UNIV CONNECTICUT,CTR HLTH,DEPT BIOCHEM,FARMINGTON,CT 06030

[2] UNIV NOTTINGHAM,DEPT APPL BIOCHEM & FOOD SCI,LOUGHBOROUGH LE12 5RD,LEICS,ENGLAND

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1994年 / 60卷 / 07期

关键词：

D O I：

10.1128/AEM.60.7.2647-2649.1994

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Wild-type spores of Bacillus subtilis were resistant to eight cycles of freeze-drying, whereas about 90% of spores lacking the two major DNA-binding proteins (small, acid-soluble proteins alpha and beta) were killed by three to four cycles of freeze-dryings, with significant mutagenesis and DNA damage accompanying the killing. This role for alpha/beta-type small, acid-soluble proteins in spore resistance to freeze-drying may be important;in spore survival in the environment.

引用

页码：2647 / 2649

页数：3

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