CHARACTERIZATION OF RECOMBINANT TETANUS TOXIN DERIVATIVES SUITABLE FOR VACCINE DEVELOPMENT

被引：34

作者：

FIGUEIREDO, D

TURCOTTE, C

FRANKEL, G

LI, Y

DOLLY, O

WILKIN, G

MARRIOTT, D

FAIRWEATHER, N

DOUGAN, G

机构：

[1] WELLCOME FDN LTD,DIV BIOL,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM,LONDON SW7,ENGLAND

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.63.8.3218-3221.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

引用

收藏

页码：3218 / 3221

页数：4

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