OPTIMIZATION AND INVIVO EVALUATIONS OF A SERIES OF SMALL, POTENT, AND SPECIFIC RENIN INHIBITORS CONTAINING A NOVEL LEU-VAL REPLACEMENT

被引：38

作者：

DELLARIA, JF

MAKI, RG

BOPP, BA

COHEN, J

KLEINERT, HD

LULY, JR

MERITS, I

PLATTNER, JJ

STEIN, HH

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 11期

关键词：

D O I：

10.1021/jm00394a035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2137 / 2144

页数：8

共 13 条

[1]

BANGHAM DR, 1975, CLIN SCI MOL MED, V48, P1355

[2] RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE [J].

BOGER, J ;

PAYNE, LS ;

PERLOW, DS ;

LOHR, NS ;

POE, M ;

BLAINE, EH ;

ULM, EH ;

SCHORN, TW ;

LAMONT, BI ;

LIN, TY ;

KAWAI, M ;

RICH, DH ;

VEBER, DF .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1779-1790

[3]

BOPP BA, UNPUB

[4] PURIFICATION OF HUMAN RENIN SUBSTRATE [J].

DORER, FE ;

LENTZ, KE ;

KAHN, JR ;

LEVINE, M ;

SKEGGS, LT .

ANALYTICAL BIOCHEMISTRY, 1978, 87 (01) :11-18

[5] A SYNTHESIS OF PROTECTED AMINOALKYL EPOXIDES FROM ALPHA-AMINO-ACIDS [J].

LULY, JR ;

DELLARIA, JF ;

PLATTNER, JJ ;

SODERQUIST, JL ;

YI, N .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (08) :1487-1492

[6]

LULY JR, UNPUB

[7]

MYCEK M, 1970, METHOD ENZYMOL, V19, P286

[8] ENZYMES OF THE RENIN-ANGIOTENSIN SYSTEM AND THEIR INHIBITORS [J].

ONDETTI, MA ;

CUSHMAN, DW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1982, 51 :283-308

[9] RENIN-ANGIOTENSIN SYSTEM - BIOCHEMISTRY AND MECHANISMS OF ACTION [J].

PEACH, MJ .

PHYSIOLOGICAL REVIEWS, 1977, 57 (02) :313-370

[10] NOVEL RENIN INHIBITORS CONTAINING ANALOGS OF STATINE RETRO-INVERTED AT THE C-TERMINI - SPECIFICITY AT THE P2 HISTIDINE SITE [J].

ROSENBERG, SH ;

PLATTNER, JJ ;

WOODS, KW ;

STEIN, HH ;

MARCOTTE, PA ;

COHEN, J ;

PERUN, TJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (07) :1224-1228

← 1 2 →