ANOMALOUS BRAIN MORPHOLOGY ON MAGNETIC-RESONANCE IMAGES IN WILLIAMS SYNDROME AND DOWN SYNDROME

被引:158
作者
JERNIGAN, TL
BELLUGI, U
机构
[1] VET ADM MED CTR,SAN DIEGO,CA 92161
[2] SALK INST BIOL STUDIES,COGNIT NEUROSCI LAB,SAN DIEGO,CA 92138
关键词
D O I
10.1001/archneur.1990.00530050049011
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Quantitative studies of brain morphology in a group of subjects with Williams syndrome revealed a distinctive pattern of dysmorphology unlike that observed in another form of mental retardation, Down syndrome. Reduced cerebral size but normal cerebellar size was observed in Williams syndrome, in contrast to reductions in both brain components in Down syndrome. Examination of cerebellar vermal morphology suggested significantly increased area of neocerebellar vermal lobules in Williams syndrome, with low-normal size in the paleocerebellar vermal lobules. Thus, a highly selective effect on brain development appears to accompany Williams syndrome, with some brain subsystems, possibly later-developing ones, relatively spared. © 1990, American Medical Association. All rights reserved.
引用
收藏
页码:529 / 533
页数:5
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