PREPARATION OF ALPHA-SUBSTITUTED BETA-ALANINE DERIVATIVES FROM 5-SUBSTITUTED URACILS AND DIHYDROURACILS

被引:12
作者
DIETRICH, RF [1 ]
SAKURAI, T [1 ]
KENYON, GL [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
关键词
D O I
10.1021/jo01325a040
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In the course of synthesizing new cyclic analogues of creatine to examine the substrate specificity of the enzyme creatine kinase, we needed reasonable quantities of both 2, 3-diaminopropanoic acid (1) and 2-(methylamino)-3-aminopropanoic acid (2). Compound 1 is available commercially at high cost and can be prepared as the dihydrobromide from 2, 3-dibromopropanoic acid and ammonia, but the yield is only 40-50% and high temperatures and pressure are required. © 1979, American Chemical Society. All rights reserved.
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页码:1894 / 1896
页数:3
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