NALOXONE INHIBITS OXYTOCIN RELEASE AT ORGASM IN MAN

被引：85

作者：

MURPHY, MR

CHECKLEY, SA

SECKL, JR

LIGHTMAN, SL

机构：

[1] INST PSYCHIAT, LONDON SE5 8AF, ENGLAND

[2] WESTMINSTER MED SCH & HOSP, CHARING CROSS & WESTMINSTER MED SCH, DEPT MED, LONDON SW1P 2AP, ENGLAND

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1990年 / 71卷 / 04期

关键词：

D O I：

10.1210/jcem-71-4-1056

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the effect of naloxone on plasma oxytocin levels during sexual activity in men. Eight normal men took part in a double-blind, two-period, cross-over design. Mean plasma oxytocin rose to 362% of baseline values at orgasm with placebo (saline) but showed no increase with naloxone (P < 0.01). While naloxone had no effect on heart rate or blood pressure at orgasm, a decrease in the level of subjective arousal and pleasure at orgasm was noted. We conclude that opioid receptor blockade with naloxone has an inhibitory effect on the neural pathways mediating the oxytocin response at orgasm. © 1990 by The Endocrine Society.

引用

页码：1056 / 1058

页数：3

共 18 条

[1] ENDOGENOUS OPIATES REGULATE OXYTOCIN BUT NOT VASOPRESSIN SECRETION FROM THE NEUROHYPOPHYSIS [J].