SOLID-PHASE EXTRACTION OF FLUOXETINE AND NORFLUOXETINE FROM SERUM WITH GAS-CHROMATOGRAPHY ELECTRON-CAPTURE DETECTION

被引：43

作者：

DIXIT, V ^{[1
]}

NGUYEN, H ^{[1
]}

DIXIT, VM ^{[1
]}

机构：

[1] VARIAN SAMPLE PREPARAT PROD,24201 FRAMPTON AVE,HARBOR CITY,CA 90710

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 563卷 / 02期

关键词：

D O I：

10.1016/0378-4347(91)80045-E

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid, selective, and sensitive method is described for the purification and analysis of fluoxetine and norfluoxetine using a solid-phase extraction column and gas chromatography-electron-capture detection. Linear quantitative response curves for fluoxetine and norfluoxetine are generated over a concentration range of 20-200 ng/ml. Overall extraction efficiency of the extraction procedure is found to be > 90% and > 75% with correlation coefficients of 0.997 and 0.993 for fluoxetine and norfluoxetine, respectively.

引用

页码：379 / 384

页数：6

共 10 条

[1] LIQUID-CHROMATOGRAPHIC SEPARATION OF ANTI-DEPRESSANT DRUGS .1. TRICYCLICS
BEIERLE, FA
HUBBARD, RW
[J]. THERAPEUTIC DRUG MONITORING, 1983, 5 (03) : 279 - 292
[2] FLUOXETINE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC EFFICACY IN DEPRESSIVE-ILLNESS
BENFIELD, P
HEEL, RC
LEWIS, SP
[J]. DRUGS, 1986, 32 (06) : 481 - 508
[3] DAVIDSON T, 1989, TOXICOL LAB NEWS, V4, P4
[4] DITO WR, 1979, DIAGN MED, V5, P48
[5] KOTEEL P, 1982, CLIN CHEM, V28, P462
[6] ANALYSIS OF TRICYCLIC ANTIDEPRESSANT DRUGS IN PLASMA AND SERUM BY CHROMATOGRAPHIC TECHNIQUES
NORMAN, TR
MAGUIRE, KP
[J]. JOURNAL OF CHROMATOGRAPHY, 1985, 340 (MAY): : 173 - 197
[7] ORSULAK PJ, 1988, CLIN CHEM, V34, P1875
[8] PROELSS HF, 1978, CLIN CHEM, V24, P1948
[9] Roberts G M, 1986, Biomed Chromatogr, V1, P49, DOI 10.1002/bmc.1130010202
[10] SCOGGINS BA, 1980, CLIN CHEM, V26, P805

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