GABA-A AND GABA-B ANTAGONISTS PREVENT THE OPIOID INHIBITION OF ENDOGENOUS ACETYLCHOLINE-RELEASE EVOKED BY GLUTAMATE FROM RAT NEOSTRIATAL SLICES

被引：11

作者：

ARENAS, E ^{[1
]}

MARSAL, J ^{[1
]}

ALBERCH, J ^{[1
]}

机构：

[1] UNIV BARCELONA,HOSP BELLVITGE,FAC MED,DEPT BIOL CELLULAR & ANAT PATOL,E-08036 BARCELONA,SPAIN

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 02期

关键词：

GLUTAMATE; ACETYLCHOLINE RELEASE; OPIATE; BICUCULLINE; PHACLOFEN; NEOSTRIATUM;

D O I：

10.1016/0304-3940(90)90038-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined the role of the GABAergic system in the opioid inhibition of endogenous acetylcholine (ACh) release from rat neostriatal slices by blocking either gamma-aminobutyric acid-A (GABA(A)) or GABA(B) receptors. GABAergic antagonists (bicuculline or phaclofen) completely blocked mu-(morphine or DAGO) and delta-opioid (DPDPE) inhibition of glutamate-evoked endogenous ACh release in a concentration-dependent manner. However, GABA antagonists were ineffective in blocking the opioid inhibition of potassium-evoked endogenous ACh release. These findings point to the important role of the GABAergic system in the system in the regulation of mu- and delta-opioid inhibition of cholinergic neurons stimulated by glutamate.

引用

页码：201 / 204

页数：4

共 23 条

[1]

ALBERCH J, 1985, IRCS MED SCI-BIOCHEM, V13, P948

[2] EXCITATORY AMINO-ACIDS RELEASE ENDOGENOUS ACETYLCHOLINE FROM RAT STRIATAL SLICES - REGULATION BY GAMMA-AMINOBUTYRIC-ACID [J].