ABNORMAL CONDUCTION IN CORTICOSPINAL PATHWAYS IN WILSONS-DISEASE - INVESTIGATION OF 9 CASES WITH MAGNETIC BRAIN-STIMULATION

被引：20

作者：

MEYER, BU

BRITTON, TC

BISCHOFF, C

MACHETANZ, J

BENECKE, R

CONRAD, B

机构：

[1] Department of Neurology, Technical University in Munich, Munich

[2] Department of Neurology, Heinrich Heine University in Düsseldorf, Düsseldorf

来源：

MOVEMENT DISORDERS | 1991年 / 6卷 / 04期

关键词：

WILSONS DISEASE; MOTOR RESPONSES;

D O I：

10.1002/mds.870060409

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Electromyographic (EMG) responses evoked by transcranial magnetic brain stimulation were studied in nine patients with Wilson's disease (WD). Six of the nine patients had prolonged central motor latencies (CMLs), reduced amplitude, or absent responses in at least one of the examined muscles. In one patient, abnormal EMG responses normalized following treatment with penicillamine. Pathophysiologically abnormal EMG responses might result from a potentially reversible impairment of corticomotoneuronal pathways and/or a reduced excitability of motoneurons due to basal ganglia dysfunction. The possible pathophysiological mechanisms are discussed.

引用

页码：320 / 323

页数：4

共 17 条

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