PENTOXIFYLLINE DOES NOT ACT VIA ADENOSINE RECEPTORS IN THE INHIBITION OF THE SUPEROXIDE ANION PRODUCTION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES

被引：42

作者：

THIEL, M ^{[1
]}

BARDENHEUER, H ^{[1
]}

POCH, G ^{[1
]}

MADEL, C ^{[1
]}

PETER, K ^{[1
]}

机构：

[1] GRAZ UNIV,INST PHARMACODYNAM & TOXICOL,A-8010 GRAZ,AUSTRIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81253-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inhibitory effect of adenosine (ADO) and pentoxifylline (POF) was studied alone and in combination on the N-formyl-methionyl-leucyl-phenylalanine (FMLP) stimulated superoxide anion production of human polymorphonuclear leukocytes (PMNL). The pharmacological analysis of the results of these experiments demonstrated greater than additive and independent interaction of the drugs, representing potentiation. These results reflect differences between the sites of action of ADO and POF. Accordingly, the ADO receptor antagonist 8-phenyltheophylline only diminished the inhibition mediated by ADO, but totally failed to affect POF. Therefore, we hypothesize that POF acts as a phosphodiesterase inhibitor, potentiating the increase in cyclic AMP induced by ADO due to the stimulation of the adenylate-cyclase of human PMNL. © 1991 Academic Press, Inc.

引用

页码：53 / 58

页数：6

共 17 条

[1]

BARDENHEUER H, 1990, INTENS CARE MED S, V16, pS36

[2]

CRONSTEIN BN, 1985, J IMMUNOL, V135, P1366

[3] EFFECTS OF INHIBITORS OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE ON THE ACTIONS OF VASOACTIVE INTESTINAL PEPTIDE AND SECRETIN ON PANCREATIC ACINI [J].

GARDNER, JD ;

KORMAN, LY ;

WALKER, MD ;

SUTLIFF, VE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 242 (06) :G547-G551

[4] PENTOXIFYLLINE MODULATION OF PLASMA-MEMBRANE FUNCTIONS IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

HAND, WL ;

BUTERA, ML ;

KINGTHOMPSON, NL ;

HAND, DL .

INFECTION AND IMMUNITY, 1989, 57 (11) :3520-3526

[5]

HERRMANN R, 1988, PHARM PHYSICAL THERA, P97

[6]

IANNONE MA, 1987, TOPICS PERSPECTIVES, P2896

[7] POLYMORPHONUCLEAR LEUKOCYTE INHIBITION BY THERAPEUTIC CONCENTRATIONS OF THEOPHYLLINE IS MEDIATED BY CYCLIC-3',5'-ADENOSINE MONOPHOSPHATE [J].

NIELSON, CP ;

CROWLEY, JJ ;

MORGAN, ME ;

VESTAL, RE .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (01) :25-30

[8]

PARSONS WJ, 1988, J PHARMACOL EXP THER, V246, P1194

[9] EVALUATION OF COMBINED EFFECTS IN DOSE-RESPONSE STUDIES BY STATISTICAL COMPARISON WITH ADDITIVE AND INDEPENDENT INTERACTIONS [J].

POCH, G ;

DITTRICH, P ;

HOLZMANN, S .

JOURNAL OF PHARMACOLOGICAL METHODS, 1990, 24 (04) :311-325

[10]

POCH G, 1982, METHOD FIND EXP CLIN, V4, P371

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