MINOXIDIL SPECIFICALLY DECREASES THE EXPRESSION OF LYSINE HYDROXYLASE IN CULTURED HUMAN SKIN FIBROBLASTS

被引：24

作者：

HAUTALA, T

HEIKKINEN, J

KIVIRIKKO, KI

MYLLYLA, R

机构：

[1] UNIV OULU, BIOCTR, COLLAGEN RES UNIT, KAJAANINTIE 52A, SF-90220 OULU, FINLAND

[2] UNIV OULU, DEPT MED BIOCHEM, SF-90220 OULU, FINLAND

来源：

BIOCHEMICAL JOURNAL | 1992年 / 283卷

关键词：

D O I：

10.1042/bj2830051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The level of lysine hydroxylase protein and the levels of the mRNAs for lysine hydroxylase and the alpha- and beta-subunits of proline 4-hydroxylase were measured in cultured human skin fibroblasts treated with 1 mM-minoxidil. The data demonstrate that minoxidil decreases the amount of lysine hydroxylase protein, this being due to a decrease in the level of lysine hydroxylase mRNA. The effect of minoxidil appears to be highly specific, as no changes were observed in the amounts of mRNAs for the alpha- and beta-subunits of proline 4-hydroxylase.

引用

页码：51 / 54

页数：4

共 24 条

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