ANGIOTENSIN-II STIMULATION OF THE RAT PITUITARY TUMORAL CELL-PROLIFERATION INVITRO

被引：16

作者：

KUNERTRADEK, J ^{[1
]}

PAWLIKOWSKI, M ^{[1
]}

机构：

[1] MED ACAD LODZ,INST ENDOCRINOL,STERLING 3,LODZ,POLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91603-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of angiotensin II (AT II) on proliferation of rat pituitary tumoral cells was investigated in vitro. The tumoral cells were isolated from the prolactin-secreting pituitary tumors induced by stilboestrol implantation. The incorporation of [3H]-thymidine into DNA was used as an index of cell proliferation. It was found that AT II significantly enhanced the [3H]-thymidine incorporation into pituitary tumoral cells in the concentrations of 10-10 and 10-8M. The stimulatory effect disappeared at the concentration of 10-6M. The possible involvement of pituitary renin-angiotensin system in pituitary tumorigenesis was discussed. © 1992.

引用

页码：27 / 30

页数：4

共 15 条

[1]

BURROWS H, 1936, AM J CANCER, V28, P741

[2]

DESCHEPPER CF, 1988, FRONT NEUROENDOCRIN, V10, P79

[3] EVIDENCE THAT THE GONADOTROPHS ARE THE LIKELY SITE OF PRODUCTION OF ANGIOTENSIN-II IN THE ANTERIOR-PITUITARY OF THE RAT [J].

DESCHEPPER, CF ;

CRUMRINE, DA ;

GANONG, WF .

ENDOCRINOLOGY, 1986, 119 (01) :36-43

[4] ANALYSIS BY IMMUNOCYTOCHEMISTRY AND INSITU HYBRIDIZATION OF RENIN AND ITS MESSENGER-RNA IN KIDNEY, TESTIS, ADRENAL, AND PITUITARY OF THE RAT [J].

DESCHEPPER, CF ;

MELLON, SH ;

CUMIN, F ;

BAXTER, JD ;

GANONG, WF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7552-7556

[5] ANGIOTENSIN STIMULATION OF BOVINE ADRENOCORTICAL CELL-GROWTH [J].

GILL, GN ;

ILL, CR ;

SIMONIAN, MH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5569-5573

[6] CHARACTERIZATION OF ANGIOTENSIN-RECEPTORS IN THE ANTERIOR-PITUITARY GLAND [J].

HAUGER, RL ;

AGUILERA, G ;

BAUKAL, AJ ;

CATT, KJ .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1982, 25 (02) :203-212

[7]

HIROSE S, 1982, RENIN ANGIOTENSIN SY, P53

[8] THE MAS ONCOGENE ENCODES AN ANGIOTENSIN RECEPTOR [J].

JACKSON, TR ;

BLAIR, LAC ;

MARSHALL, J ;

GOEDERT, M ;

HANLEY, MR .

NATURE, 1988, 335 (6189) :437-440

[9] ROLE OF ANGIOTENSIN ON PARACRINE PROLACTIN-RELEASE IN THE PITUITARY-GLAND AND ITS POSSIBLE EFFECTS ON OVARIAN-FUNCTION [J].

KUBOTA, T ;

ASO, T .

HORMONE RESEARCH, 1991, 35 :13-20

[10]

LI C, 1989, CLIN RES, V37, pA940

← 1 2 →