REGIOSELECTIVE SYNTHESIS OF 4-ACETYL-3-METHYLISOXAZOLE AND 5-ACETYL-3-METHYLISOXAZOLE - THEIR CONVERSION INTO SILYL-ENOL AND METHYL-ENOL ETHERS

被引：4

作者：

CHIMICHI, S ^{[1
]}

COSIMELLI, B ^{[1
]}

机构：

[1] I-50121 FLORENCE, ITALY

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 20期

关键词：

D O I：

10.1080/00397919208021114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acetonitrile oxide reacts regioselectively with 3-buten-2-one and (E)-4-methoxy-3-buten-2-one to give 5-acetyl- 2 and 4-acetyl-3-methylisoxazole 3, respectively. Treatment of ketones 2 and 3 with trimethylsilyl trifluoromethanesulfonate gave the silyl enol ethers 4 and 5, whereas the methyl enol ethers 8 and 9 were obtained via elimination of methanol from the corresponding dimethyl ketals.

引用

页码：2909 / 2920

页数：12

共 21 条

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[4]

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