THERMAL-STRESS AS AN INDUCER OF DIFFERENTIATION OF U937 CELLS

被引：12

作者：

CELLIER, MFM ^{[1
]}

TAIMI, M ^{[1
]}

CHATEAU, MT ^{[1
]}

CANNAT, A ^{[1
]}

MARTI, J ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2, BIOL CELLULAIRE LAB,INSERM,U65,DEPT BIOL SANTE, CP 100, F-34095 MONTPELLIER 5, FRANCE

来源：

LEUKEMIA RESEARCH | 1993年 / 17卷 / 08期

关键词：

U937; HEAT SHOCK; RETINOIC ACID; VITAMIN-D; CELL DIFFERENTIATION; MYELOMONOCYTIC CELLS;

D O I：

10.1016/0145-2126(93)90069-W

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The individual and combined effects of heat shock, all-trans retinoic acid and 1,25-dihydroxyvitamin D3 on inhibition of cell growth and initiation of differentiation were investigated on U937 human leukemia cells. Incubation of U937 cells at 43-degrees-C for 1 h did not affect cell viability but induced a reduction of cell growth and the emergence of a differentiated phenotype, characterized by the acquisition of chemiluminescent responses to various oxidative burst inducers and by the capacity to produce IL-6 in response to bacterial lipopolysaccharide. Heat shock alone, therefore, appears to be an efficient inducer of cell differentiation. In addition, heat shock primed the cells to respond more efficiently to the action of retinoic acid and vitamin D, and amplified the phenotypic changes initiated by pretreatment of U937 cells with these agents.

引用

页码：649 / 656

页数：8

共 51 条

[1] INDUCTION OF SYNTHESIS OF COMPONENTS OF THE HYDROGEN PEROXIDE-GENERATING OXIDASE DURING ACTIVATION OF THE HUMAN MONOCYTIC CELL-LINE U937 BY INTERFERON-GAMMA [J].