LEUKEMIC INTERMEDIATE LYMPHOCYTIC LYMPHOMAS - ANALYSIS OF 12 CASES DIAGNOSED BY MORPHOLOGY

被引：18

作者：

CRIEL, A

BILLIET, J

VANDENBERGHE, E

VANDENBERGHE, H

LOUWAGIE, A

HIDAJAT, M

VANHOOF, A

机构：

[1] Department of Haematology, Brugge, A.Z. St. Jan

[2] Centre for Human Genetics, University of Leuven, Leuven

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 8卷 / 4-5期

关键词：

NHL; INTERMEDIATE LYMPHOMA; T(11; 14); CYTOLOGICAL DIAGNOSIS; IMMUNOLOGICAL DIAGNOSIS; SPECIAL FEATURES;

D O I：

10.3109/10428199209051018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twelve cases of leukaemic intermediate diffuse lymphocytic lymphoma (ILL), diagnosed by morphology, were analysed. The morphology of the ILL cells was so typical that it allowed ready distinction from chronic lymphocytic leukaemia (CLL) and other related B cell disorders. All cases were of B derivation, had strong mu and x or lambda immunoglobulin (Ig) staining, were CD5 and FMC7 positive and CD10 negative. Cytogenetic abnormalities were found in 8 patients all having t(11;14)(q13;q32). DNA analysis revealed a relatively high incidence of hypoploidy. At diagnosis all the patients (9 males, 5 females; median age 68) had a low degree of absolute lymphocytosis but the disease was advanced and mostly widespread. The course of the disease appears to be aggressive and incurable with conventional combination chemotherapy.

引用

页码：381 / 387

页数：7

共 19 条

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