SITE-SPECIFIC GENETIC-RECOMBINATION - HOPS, FLIPS, AND FLOPS

被引：101

作者：

SADOWSKI, PD

机构：

[1] Dept. of Molecular/Medical Genetics, University of Toronto, Toronto

来源：

FASEB JOURNAL | 1993年 / 7卷 / 09期

关键词：

TRANSPOSONS; SITE-SPECIFIC RECOMBINATION; TARGET SEQUENCE;

D O I：

10.1096/fasebj.7.9.8392474

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic recombination plays a key role in the life of organisms as diverse as bacteriophages and humans. Contrary to our idea that chromosomes are stable structures, studies of recombination over the past few decades have shown that in fact DNA replicons are remarkably plastic, undergoing frequent recombination-induced rearrangements. This review summarizes our recent knowledge of the biochemistry of the two major classes of site-specific recombination: 1) transpositional recombination, and 2) conservative site-specific recombination.

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页码：760 / 767

页数：8

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