DETECTION OF HIGH-MASS BIOMOLECULES IN FOURIER-TRANSFORM ION-CYCLOTRON RESONANCE MASS-SPECTROMETRY - THEORETICAL AND EXPERIMENTAL INVESTIGATIONS

被引：39

作者：

SOLOUKI, T ^{[1
]}

GILLIG, KJ ^{[1
]}

RUSSELL, DH ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

来源：

ANALYTICAL CHEMISTRY | 1994年 / 66卷 / 09期

关键词：

D O I：

10.1021/ac00081a037

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple modification to an ion cyclotron resonance (ICR) cell for detection of high-mass ions with large spatial and kinetic energy distributions is described. The modification consists of a copper wire positioned inside the ICR cell running parallel to the magnetic field lines. The wire sets as an ion guide to position the ions at the exact center of the ion cell. Ion trajectories are calculated using SIMION, and the predictions based on the calculations are compared with the experimental results. The results presented in this paper show that the ion-guide ICR cell can be used to detect singly charged biomolecule ions of up to 157 000 Da.

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页码：1583 / 1587

页数：5

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