HPV16 E7 ONCOPROTEIN INDUCES EXPRESSION OF A 110 KDA HEAT-SHOCK PROTEIN

被引：15

作者：

MOROZOV, A

SUBJECK, J

RAYCHAUDHURI, P

机构：

[1] UNIV ILLINOIS,DEPT BIOCHEM MC 536,CHICAGO,IL 60612

[2] ROSWELL PK CANC INST,DEPT MOLEC & CELL BIOL,BUFFALO,NY 14263

来源：

FEBS LETTERS | 1995年 / 371卷 / 03期

关键词：

HUMAN PAPILLOMAVIRUS; E7; HEAT SHOCK PROTEIN;

D O I：

10.1016/0014-5793(95)00884-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heat shock protein genes are induced by various kinds of stress, Besides stress, the heat shock family gene hsp70 has been shown to be induced by growth-stimulating agents such as the DNA virus oncoproteins and serum, Here, we report cloning of a novel cDNA that encodes a 100 kDa heat shock protein-related polypeptide as a human papillomavirus oncoprotein E7-inducible gene, E7 induces expression of this heat shock protein at the level of RNA synthesis, Moreover, the induction of this heat shock protein-mRNA mas dependent on the conserved region 2 of the E7 protein, which is essential for binding to the proteins of the retinoblastoma family.

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页码：214 / 218

页数：5

相关论文

共 28 条

[1] MAMMALIAN HEAT-SHOCK PROTEIN FAMILIES - EXPRESSION AND FUNCTIONS [J].

BUREL, C ;

MEZGER, V ;

PINTO, M ;

RALLU, M ;

TRIGON, S ;

MORANGE, M .

EXPERIENTIA, 1992, 48 (07) :629-634

[2]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[3]

FATHALLAH DM, 1993, J IMMUNOL, V151, P810

[4] FOLDING OF NASCENT POLYPEPTIDE-CHAINS IN A HIGH-MOLECULAR-MASS ASSEMBLY WITH MOLECULAR CHAPERONES [J].

FRYDMAN, J ;

NIMMESGERN, E ;

OHTSUKA, K ;

HARTL, FU .

NATURE, 1994, 370 (6485) :111-117

[5] STIMULATION OF 3T3 CELLS INDUCES TRANSCRIPTION OF THE C-FOS PROTO-ONCOGENE [J].

GREENBERG, ME ;

ZIFF, EB .

NATURE, 1984, 311 (5985) :433-438

[6] CHARACTERIZATION OF HIGH-MOLECULAR-MASS HEAT-SHOCK PROTEINS AND 42-DEGREES-C-SPECIFIC HEAT-SHOCK PROTEINS OF MURINE CELLS [J].

HATAYAMA, T ;

YASUDA, K ;

NISHIYAMA, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 204 (01) :357-365

[7] CELLULAR-LOCALIZATION OF HIGH-MOLECULAR-MASS HEAT-SHOCK PROTEINS IN MURINE CELLS [J].

HATAYAMA, T ;

NISHIYAMA, E ;

YASUDA, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (03) :1367-1373

[8] IDENTIFYING DIFFERENCES IN MESSENGER-RNA EXPRESSION BY REPRESENTATIONAL DIFFERENCE ANALYSIS OF CDNA [J].

HUBANK, M ;

SCHATZ, DG .

NUCLEIC ACIDS RESEARCH, 1994, 22 (25) :5640-5648

[9] HPV16 E7 ONCOPROTEIN DEREGULATES B-MYB EXPRESSION - CORRELATION WITH TARGETING OF P107/E2F COMPLEXES [J].

LAM, EWF ;

MORRIS, JDH ;

DAVIES, R ;

CROOK, T ;

WATSON, RJ ;

VOUSDEN, KH .

EMBO JOURNAL, 1994, 13 (04) :871-878

[10] ADENOVIRUS E1A ACTIVATION DOMAIN BINDS THE BASIC REPEAT IN THE TATA BOX TRANSCRIPTION FACTOR [J].

LEE, WS ;

KAO, CC ;

BRYANT, GO ;

LIU, X ;

BERK, AJ .

CELL, 1991, 67 (02) :365-376