USE OF DIFFERENT CARRIERS TO DEMONSTRATE THYMIC-DEPENDENT AND THYMIC-INDEPENDENT ANTI-TRINITROPHENYL REACTIVITY IN THE AMPHIBIAN XENOPUS-LAEVIS

被引：16

作者：

HORTON, JD ^{[1
]}

EDWARDS, BF ^{[1
]}

RUBEN, LN ^{[1
]}

METTE, S ^{[1
]}

机构：

[1] REED COLL,DEPT BIOL,PORTLAND,OR 97202

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 1979年 / 3卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0145-305X(79)80057-9

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Anti-trinitrophenyl (TNP) rosette forming cell reactivity can be demonstrated in spleens of control Xenopus Zaevis following a single in vivo injection of either TNP-LPS (trinitrophenylated lipolysaccharide) or TNP-Ficoll (trinitrophenylated Ficoll). TNP-SRBC (trinitrophenylated sheep red blood cells) immunisation is also effective in this respect, but this antigen requires low-dose carrier (SRBC) priming to achieve significant levels of TNP-binding lymphocytes. Thymectomized toadlets respond normally to TNP-LPS, but splenic reactivity to both TNP-SRBC and TNP-Ficoll is virtually abolished. We suggest that the amphibian thymus is not only the source of T cells that cooperate in humoral immunity, but that this organ also plays a vital role in the maturation of some B-equivalent" lymphocyte populations. © 1979 Pergamon Press Ltd. All rights reserved."

引用

页码：621 / 633

页数：13

共 31 条

[1] ANTIBODY-PRODUCTION TO LIPOPOLYSACCHARIDE IN THYMECTOMIZED XENOPUS [J].