CATION BINDING TO BIOMOLECULES .6. SCF ABINITIO (PSEUDOPOTENTIAL) COMPUTATIONS ON THE INTERACTION OF ZN2+ WITH THE PURINE AND PYRIMIDINE-BASES OF THE NUCLEIC-ACIDS

被引：25

作者：

PULLMAN, A

EBBESEN, T

RHOLAM, M

机构：

[1] Laboratoire de Biochimie Théorique associé au C.N.R.S., Institut de Biologie Physico-Chimique, Paris, F-75005, 13, rue P. et M. Curie

来源：

THEORETICA CHIMICA ACTA | 1979年 / 51卷 / 03期

关键词：

Zn[!sup]2+[!/sup] binding to nucleic acid bases;

D O I：

10.1007/BF00572931

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The binding of Zn2+ to the purine and pyrimidine bases of the nucleic acids was studied by SCF ab initio (pseudopotential) computations. The order of affinity of the bases is guanine ≃ cytosine > adenine ≫ uracil. Many geometrical features of the binding are similar to those observed previously in the interaction of the bases with Na+. A new feature is the possibility of chelation by Zn2+ between N7 and the rotated NH2 group of adenine. © 1979 Springer-Verlag.

引用

页码：247 / 254

页数：8

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