CHRONIC LEAD TREATMENT DIFFERENTIALLY AFFECTS DOPAMINE SYNTHESIS IN VARIOUS RAT-BRAIN AREAS

被引：73

作者：

GOVONI, S

MEMO, M

SPANO, PF

TRABUCCHI, M

机构：

[1] UNIV MILAN, DEPT PHARMACOL & PHARMACOGNOSY, I-20132 MILAN, ITALY

[2] UNIV BRESCIA, DEPT PHARMACOL & THERAPEUT, BRESCIA, ITALY

来源：

TOXICOLOGY | 1979年 / 12卷 / 03期

关键词：

D O I：

10.1016/0300-483X(79)90081-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of chronic dietary lead exposure on brain nigrostriatal, mesolimbic and mesocortial systems was studied. The results show no modification of the dopamine receptors measured either as dopamine sensitive adenylate cyclase or as [3H]spiroperidol binding. On the other hadn, dopamine synthesis seems to be reduced in striatum, unaffected in substantia nigra and increased in nucleus accumbens and in the frontal cortex. The increase of DA synthesis observed in some brain areas might be involved in determining the hyperactive behaviour that follows lead intoxication. © 1979.

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页码：343 / 349

页数：7

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