CONJUGATION AND EXCRETION OF METABOLITES OF 7-HYDROXYCOUMARIN IN THE SMALL-INTESTINE OF RATS AND GUINEA-PIGS

被引：17

作者：

DAWSON, JR ^{[1
]}

BRIDGES, JW ^{[1
]}

机构：

[1] UNIV SURREY, INST IND & ENVIRONM HLTH & SAFETY, GUILDFORD GU2 5XH, SURREY, ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 22期

关键词：

D O I：

10.1016/0006-2952(79)90124-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

7-Hydroxycoumarin is conjugated with glucuronic acid and sulfate in intestinal preparations of both rats and guinea-pigs. The highest activity was found at the oral end of the small intestine and the lowest activity at the aboral end. Some distributional differences between the glucuronyl transferase(s) and sulfotransferase(s) were observed. In both gut sacs and in situ preparations a considerable secretion of conjugate into the lumen was found. The significance of this finding to chemical toxicity in the lower gut is discussed.

引用

页码：3291 / 3297

页数：7

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