ADENOSINE-DEAMINASE REDUCES HYPOXIC AND HYPERCAPNIC DILATATION OF RAT PIAL ARTERIOLES - EVIDENCE FOR MEDIATION BY ADENOSINE

被引：27

作者：

SIMPSON, RE ^{[1
]}

PHILLIS, JW ^{[1
]}

机构：

[1] WAYNE STATE UNIV, SCH MED, DEPT PHYSIOL, DETROIT, MI 48201 USA

来源：

BRAIN RESEARCH | 1991年 / 553卷 / 02期

关键词：

ADENOSINE DEAMINASE; ADENOSINE; ARTERIOLE; DILATATION; HYPERCAPNIA; HYPOXIA;

D O I：

10.1016/0006-8993(91)90839-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rat pial arteries were observed through a closed cranial window during hypercapnic and hypoxic episodes whilst the cerebral cortex was superfused at 37-degrees-C first with artificial cerebrospinal fluid (CSF) and subsequently with adenosine deaminase (ADA, 0.5-2.0 U/ml) in CSF. The results indicate that ADA attenuated hypercapnic and hypoxic dilatatory arteriolar responses by 64% and 56% respectively. Recovery was obtained by superfusing with ADA-free CSF for 1 h. We conclude that adenosine is involved in hypercapnia- and hypoxia-evoked dilation of pial arteries.

引用

页码：305 / 308

页数：4

共 21 条

[1] RELEASE OF ADENOSINE FROM ISCHEMIC BRAIN - EFFECT ON CEREBRAL VASCULAR-RESISTANCE AND INCORPORATION INTO CEREBRAL ADENINE-NUCLEOTIDES [J].

BERNE, RM ;

RUBIO, R ;

CURNISH, RR .

CIRCULATION RESEARCH, 1974, 35 (02) :262-271

[2]

DORA E, 1986, ACTA PHYSIOL HUNG, V68, P183

[3] ADENOSINE RESPONSE ON PIAL-ARTERIES, INFLUENCE OF CO2 AND BLOOD-PRESSURE [J].

GREGORY, PC ;

BOISVERT, DPJ ;

HARPER, AM .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1980, 386 (02) :187-192

[4] MODERATE HYPOXIA - REACTIVITY OF PIAL-ARTERIES AND LOCAL EFFECT OF THEOPHYLLINE [J].

HALLER, C ;

KUSCHINSKY, W .

JOURNAL OF APPLIED PHYSIOLOGY, 1987, 63 (06) :2208-2215

[5] THE ROLE OF ADENOSINE IN CBF INCREASES DURING HYPOXIA IN YOUNG VS AGED RATS [J].

HOFFMAN, WE ;

ALBRECHT, RF ;

MILETICH, DJ .

STROKE, 1984, 15 (01) :124-129

[6]

KONTOS HA, 1981, FED PROC, V40, P454

[7] REACTIVITY OF RAT PIAL ARTERIOLES AND VENULES TO ADENOSINE AND CARBON-DIOXIDE - WITH DETAILED DESCRIPTION OF THE CLOSED CRANIAL WINDOW TECHNIQUE IN RATS [J].

MORII, S ;

NGAI, AC ;

WINN, HR .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1986, 6 (01) :34-41

[8] ROLE OF ADENOSINE IN REGULATION OF CEREBRAL BLOOD-FLOW - EFFECTS OF THEOPHYLLINE DURING NORMOXIA AND HYPOXIA [J].

MORII, S ;

NGAI, AC ;

KO, KR ;

WINN, HR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (01) :H165-H175

[9] COMPARISON OF THE OPEN SKULL AND CRANIAL WINDOW PREPARATIONS IN THE STUDY OF THE CEREBRAL MICROCIRCULATION [J].

NAVARI, RM ;

WEI, EP ;

KONTOS, HA ;

PATTERSON, JL .

MICROVASCULAR RESEARCH, 1978, 16 (03) :304-315

[10] EFFECT OF INOSINE ON PIAL ARTERIOLES - POTENTIATION OF ADENOSINE-INDUCED VASODILATION [J].

NGAI, AC ;

MONSEN, MR ;

IBAYASHI, S ;

KO, KR ;

WINN, HR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (03) :H603-H606

← 1 2 3 →