RADIOSENSITIZATION OF HYPOXIC TUMOR-CELLS BY CIS-DICHLORODIAMMINEPLATINUM(II) AND TRANS-DICHLORODIAMMINEPLATINUM(II)

被引：104

作者：

DOUPLE, EB

RICHMOND, RC

机构：

[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DEPT RADIAT THERAPY,HANOVER,NH 03755

[2] BOSTON UNIV,SCH MED,DEPT RADIOL & RADIAT MED,BOSTON,MA 02215

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Cis-dichlorodiammineplatinum(II); Combination chemotherapy-radiotherapy; Mouse mammary adenocarcinoma (MTG-B); Platinum coordination complexes; Radiosensitization; Tumor latency assay;

D O I：

10.1016/0360-3016(79)90672-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of the chemotherapeutic agent cis-dichlorodiammineplatinum (II) or its trans isomer on tumor cell lethality were evaluated following administration of the drugs, alone, or in combination with x-irradiation. The tumor latency method was employed to assay tumor cell survival under in vivo growth conditions following treatment in vivo. Radiosensitization of hypoxic tumor cells was demonstrated by combinations of either complex with high doses of radiation. The results extend an effect observed in bacterial systems and cultured mammalian cells to include tumor cells treated in situ. However, therapeutic potentiation during more clinically relevant treatment protocols in air-breathing mice is probably the result of the platinum complexes inhibiting recovery processes following irradiation. © 1979.

引用

页码：1369 / 1372

页数：4

共 8 条

[1]

CLIFTON KELLY H., 1963, INT J RADIAT BIOL, V7, P515, DOI 10.1080/09553006314551561

[2]

CLIFTON KH, 1966, J NATL CANCER I, V36, P965

[3]

DOUPLE E B, 1977, Journal of Clinical Hematology and Oncology, V7, P585

[4]

DOUPLE EB, 1978, BRIT J CANCER, V37, P98