TESTOSTERONE INHIBITS THE IMMUNOSTIMULANT EFFECT OF THYMOSIN FRACTION-5 ON SECONDARY IMMUNE-RESPONSE IN MICE

被引：4

作者：

CATANZANOTROUTAUD, D

ARDAIL, D

DESCHAUX, PA

机构：

[1] Laboratory of General and Comparative Immunophysiology

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1016/0192-0561(92)90038-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The purpose of the present investigation was to examine the in vivo influence of testosterone on the immune properties of a thymic factor (thymosin fraction 5, TF5) a partially purified thymic preparation in male Swiss IOPS/OF1 mice (5-1.0 weeks old). Testosterone administration (100-mu-g/ml) significantly inhibited the enhanced anti-sheep red blood cell antibody response induced by TF5 (100-mu-g/ml); this inhibition was only observed on the secondary antibody response and not on the primary. These results suggest that gonadal steroids can affect the immune response by modulating the activity of thymic factors.

引用

页码：263 / 268

页数：6

共 40 条

[1] ESTROGEN AND THYMIC HORMONE INTERACTIONS IN THE FEMALE MOUSE [J].