THE AMPLIFIER ROLE OF T-CELLS IN THE HUMAN INVITRO B-CELL RESPONSE TO TYPE-4 PNEUMOCOCCAL POLYSACCHARIDE

被引：22

作者：

GRIFFIOEN, AW ^{[1
]}

TOEBES, EAH ^{[1
]}

RIJKERS, GT ^{[1
]}

CLAAS, FHJ ^{[1
]}

DATEMA, G ^{[1
]}

ZEGERS, BJM ^{[1
]}

机构：

[1] LEIDEN UNIV,DEPT IMMUNOHAEMATOL,2300 RA LEIDEN,NETHERLANDS

来源：

IMMUNOLOGY LETTERS | 1992年 / 32卷 / 03期

关键词：

T-CELL; B-CELL; TYPE-4 PNEUMOCOCCAL POLYSACCHARIDE;

D O I：

10.1016/0165-2478(92)90060-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human B cell response to T cell independent type 2 antigens ig regulated by thymus-derived lymphocytes. We analyzed the role of T cells in the in vitro antibody response to type 4 pneumococcal polysaccharide (PS4). We here show that the amplifying effect of T cells, which has previously been shown to be radioresistant and confined to T cell preparations enriched for CD4 + cells, is MHC non-restricted as demonstrated in cultures carried out in the presence of allogeneic T cells. Also, T cell clones derived from non-related donors are able to enhance the B cell response to PS4. All TCR-alpha-beta+, CD4+ T cell clones, but none of the TCR-alpha-beta+, CD8+ T cell clones tested, enhanced the B cell response to PS4. Furthermore, 3 out of 6 TCR-gamma-delta+ T cell clones were capable of enhancing the anti-PS4 B cell response. Experiments using recombinant lymphokines and glutaraldehyde-fixed T cells indicated that both lymphokines and T-B cell interactions are required for an optimal antibody response to PS4.

引用

页码：265 / 272

页数：8

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