THE HERPES-SIMPLEX VIRUS TYPE-1 REACTIVATION FUNCTION LIES OUTSIDE THE LATENCY-ASSOCIATED TRANSCRIPT OPEN READING FRAME ORF-2

被引：23

作者：

FARRELL, MJ

HILL, JM

MARGOLIS, TP

STEVENS, JG

WAGNER, EK

FELDMAN, LT

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,INST MOLEC BIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

[3] LOUISIANA STATE UNIV,MED CTR,CTR EYE,LIONS EYE RES LABS,NEW ORLEANS,LA 70112

[4] UNIV CALIF IRVINE,DEPT MOLEC BIOL & BIOCHEM,IRVINE,CA 92717

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 06期

关键词：

D O I：

10.1128/JVI.67.6.3653-3655.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The latency-associated transcription unit has been shown to be important for in vivo reactivation of herpes simplex virus from the latent state. A recombinant virus was constructed to alter the largest open reading frame in this region. This virus had a wild-type reactivation phenotype, suggesting that herpes simplex virus does not require a protein function from this reading frame for efficient reactivation from latency.

引用

收藏

页码：3653 / 3655

页数：3

相关论文

共 28 条

[1] A HERPES-SIMPLEX VIRUS TYPE-1 LATENCY-ASSOCIATED TRANSCRIPT MUTANT REACTIVATES WITH NORMAL KINETICS FROM LATENT INFECTION [J].

BLOCK, TM ;

SPIVACK, JG ;

STEINER, I ;

DESHMANE, S ;

MCINTOSH, MT ;

LIRETTE, RP ;

FRASER, NW .

JOURNAL OF VIROLOGY, 1990, 64 (07) :3417-3426

[2] RNA FROM AN IMMEDIATE EARLY REGION OF THE TYPE-1 HERPES-SIMPLEX VIRUS GENOME IS PRESENT IN THE TRIGEMINAL GANGLIA OF LATENTLY INFECTED MICE [J].

DEATLY, AM ;

SPIVACK, JG ;

LAVI, E ;

FRASER, NW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) :3204-3208

[3] RELATIONSHIP BETWEEN POLYADENYLATED AND NONPOLYADENYLATED HERPES-SIMPLEX VIRUS TYPE-1 LATENCY-ASSOCIATED TRANSCRIPTS [J].

DEVIRAO, GB ;

GOODART, SA ;

HECHT, LM ;

ROCHFORD, R ;

RICE, MK ;

WAGNER, EK .

JOURNAL OF VIROLOGY, 1991, 65 (05) :2179-2190

[4] IDENTIFICATION OF THE LATENCY-ASSOCIATED TRANSCRIPT PROMOTER BY EXPRESSION OF RABBIT BETA-GLOBIN MESSENGER-RNA IN MOUSE SENSORY NERVE GANGLIA LATENTLY INFECTED WITH A RECOMBINANT HERPES-SIMPLEX VIRUS [J].

DOBSON, AT ;

SEDERATI, F ;

DEVIRAO, G ;

FLANAGAN, WM ;

FARRELL, MJ ;

STEVENS, JG ;

WAGNER, EK ;

FELDMAN, LT .

JOURNAL OF VIROLOGY, 1989, 63 (09) :3844-3851

[5] AN ANTIGEN ENCODED BY THE LATENCY-ASSOCIATED TRANSCRIPT IN NEURONAL CELL-CULTURES LATENTLY INFECTED WITH HERPES-SIMPLEX VIRUS TYPE-1 [J].

DOERIG, C ;

PIZER, LI ;

WILCOX, CL .

JOURNAL OF VIROLOGY, 1991, 65 (05) :2724-2727

[6] HERPES-SIMPLEX VIRUS LATENCY-ASSOCIATED TRANSCRIPT IS A STABLE INTRON [J].

FARRELL, MJ ;

DOBSON, AT ;

FELDMAN, LT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (03) :790-794

[7] THE LATENCY-ASSOCIATED TRANSCRIPTS OF HERPES-SIMPLEX VIRUS - RNA IN SEARCH OF FUNCTION [J].

FRASER, NW ;

BLOCK, TM ;

SPIVACK, JG .

VIROLOGY, 1992, 191 (01) :1-8

[8] RNA COMPLEMENTARY TO HERPES-SIMPLEX VIRUS TYPE-1 ICP0 GENE DEMONSTRATED IN NEURONS OF HUMAN TRIGEMINAL GANGLIA [J].

GORDON, YJ ;

JOHNSON, B ;

ROMANOWSKI, E ;

ARAULLOCRUZ, T .

JOURNAL OF VIROLOGY, 1988, 62 (05) :1832-1835

[9]

GORDON YJ, 1990, VIROLOGY, V174, P117

[10] HERPES-SIMPLEX VIRUS LATENT PHASE TRANSCRIPTION FACILITATES INVIVO REACTIVATION [J].

HILL, JM ;

SEDARATI, F ;

JAVIER, RT ;

WAGNER, EK ;

STEVENS, JG .

VIROLOGY, 1990, 174 (01) :117-125