VANADIUM(II)-INDUCED AND NIOBIUM(III)-INDUCED, DIASTEREOSELECTIVE PINACOL COUPLING OF PEPTIDE ALDEHYDES TO C-2-SYMMETRICAL HIV-PROTEASE INHIBITORS

被引：74

作者：

KAMMERMEIER, B ^{[1
]}

BECK, G ^{[1
]}

JACOBI, D ^{[1
]}

JENDRALLA, H ^{[1
]}

机构：

[1] LANDES ENTWICKLUNGS GESELL, D-70182 STUTTGART, GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1994年 / 33卷 / 06期

关键词：

D O I：

10.1002/anie.199406851

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Potent inhibitors of HIV‐protease such as 1 can be produced on a kilogram scale by diastereoselective, reductive dimerization of homochiral peptide aldehydes. This is made possible by the use of niobium catalysts or vanadium catalysts generated in situ in the crucial reaction step. aryl = 1‐naphthyl. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：685 / 687

页数：3

共 21 条

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