ACTIVATION OF THE NO-CGMP SIGNALING PATHWAY DEPRESSES HIPPOCAMPAL SYNAPTIC TRANSMISSION THROUGH AN ADENOSINE RECEPTOR-DEPENDENT MECHANISM

被引：43

作者：

BROOME, MR ^{[1
]}

COLLINGRIDGE, GL ^{[1
]}

IRVING, AJ ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,DEPT PHARMACOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

NEUROPHARMACOLOGY | 1994年 / 33卷 / 11期

基金：

英国惠康基金;

关键词：

NITRIC OXIDE; ADENOSINE; SNAP; ZAPRINAST; DPCPX; CGMP;

D O I：

10.1016/0028-3908(94)90056-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activation of the NO-cGMP pathway or adenosine receptors depresses reversibly synaptic transmission in the hippocampus. Here we demonstrate, using the selective Al receptor antagonist DPCPX, a convergence in the mechanisms of action of the NO donor SNAP, the cGMP phosphodiesterase inhibitor zaprinast and adenosine.

引用

页码：1511 / 1513

页数：3

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