ACQUIRED TYPE-I HYPERLIPOPROTEINEMIA WITH SYSTEMIC LUPUS ERYTHEMATOSUS, DYSGLOBULINEMIA AND HEPARIN RESISTANCE

A case of postheparin lipoprotein lipase deficient hyperchylomicronemia with associated lupus erythematosus is described. As the symptoms of lupus erythematosus progressed, chylomicronemia diminished. Abnormal heparin responsiveness could be demonstrated in vivo and in vitro in the coagulation system and in vivo by decreased postheparin lipolytic activity. It is suggested that in this case lupus erythematosus, possibly because of dysglobulinemia, was associated with abnormal heparin binding that linked the coagulation defects and hyperlipoproteinemia. © 1969.