HEPATIC N-DEMETHYLATION OF AMINOPYRINE IN RAT AND TROUT

被引：55

作者：

DEWAIDE, JH

HENDERSO.PT

机构：

[1] Institute of Pharmacology, Faculty of Medicine, University of Nijmegen

来源：

BIOCHEMICAL PHARMACOLOGY | 1968年 / 17卷 / 09期

关键词：

D O I：

10.1016/0006-2952(68)90106-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Optimal conditions have been investigated for the in vitro assay of the hepatic N-demethylation of aminopyrine in rat (Wistar) and trout (Salmo irideus). In rat and trout N-demethylase shows differences in optimum temperature, stability and substrate affinity. The pH optimum is identical. Adverse actions of nicotinamide and semi-carbazide, commonly used in the test, are discussed. It is shown that under standardized (optimal) conditions per unit of liver weight the activity of the rat is about 15 times that of the trout. The significance of this difference is discussed. © 1968.

引用

页码：1901 / &

共 26 条

[1]

ADAMSON RH, 1967, FED PROC, V26, P1047

[2] COMPARATIVE BIOCHEMISTRY OF DRUG METABOLISM BY AZO AND NITRO REDUCTASE [J].